Reference protocol: Semax
Semax is a nootropic and neuroprotective peptide dosed in the morning. Its escalation is short, and its main precaution is not physical but neuropsychiatric: it modulates dopamine, serotonin and BDNF, and that calls for respect with certain histories.
The reference for injectable Semax starts at 330 to 500 mcg per day in the morning —3.3 to 5 units at 10 mg/ml—, settles at 500 mcg in weeks 3 and 4, and rises to 1 mg —10 units— from week 5 to 8. Cycles of 6 to 8 weeks, with or without food.
First time? Follow the step-by-step guide
View product & buy →First time? Start here
Your SEMAX vial arrives as a dry powder: you mix it with a special water — that step is called reconstituting — and measure each dose with an insulin syringe. Follow the steps with the numbers for your case.
Step 1 of 6 Get what you need
Your vial, a vial of bacteriostatic water (sold separately), a 1 ml U-100 insulin syringe — ask for it exactly like that at the pharmacy — and alcohol wipes.
Step 2 of 6 Measure the water
The 10 mg vial takes 1 ml of water: one full draw to 100 — do not repeat it. Flip off the plastic cap (the rubber stopper stays on), wipe it with alcohol and let the water run down the inside wall.
Step 3 of 6 Swirl gently, never shake
Swirl the vial slowly until it turns clear — never shake it; some take a few minutes. Then it goes in the fridge (2–8 °C) and is used within 12 weeks — the limit is mainly to keep bacteria out each time the stopper is pierced. Unmixed, keep it refrigerated from the day it arrives too.
Step 4 of 6 Fill to the 3.3 mark
The numbers printed on the syringe are units (U): 100 U = 1 ml. Your dose of 330 mcg is 0.03 ml — draw up to the 3.3 mark.
Step 5 of 6 Inject under the skin
Belly area, two fingers away from the navel: alcohol, pinch the skin, insert the full needle and inject slowly. Switch sides each time and use a new syringe.
Step 6 of 6 Your schedule
Used in the morning, 5–7 days a week.
- Cycle
- 6–8 weeks · 6–8-week washout
- 330–500 mcg your dose3.3–5 Uwk 1–2
- 500 mcg5 Uwk 3–4
- 1 mg10 Uwk 5–8
Summary Done — you have the essentials
Your 10 mg vial yields 30 complete doses of 330 mcg (≈ 6 weeks).
Order or ask on WhatsApp (opens WhatsApp in a new tab)Quick dictionary — the words that stop beginners
- Reconstitute: mixing the vial's powder with the special water so it becomes a liquid you can measure.
- Bacteriostatic water: the special water for that mix (regular water will not do); sold separately — one vial covers several mixes.
- Unit (U): the insulin syringe's measure: 100 units = 1 ml. Go by the printed numbers, not by counting lines (on a 1 ml syringe each line is usually 2 U).
- U-100 syringe: the standard 1 ml insulin syringe, numbered from 0 to 100 units; sold at any pharmacy.
- mg and mcg: milligrams and micrograms: 1 mg = 1,000 mcg. Mind the factor of one thousand when reading a dose.
- Subcutaneous: an injection under the skin (not into muscle or vein), usually in the belly area.
- Cycle and washout: using the product for a period and then stopping completely for some weeks; when resuming you start again from the starting dose.
Quick facts
| Parameter | Reference |
|---|---|
| Frequency | 1 daily dose, 5–7 days per week |
| Time of day | In the morning |
| Fasting | Not required — with or without food |
| Cycle | 6–8 weeks · 6–8-week washout |
| Documented route | Subcutaneous injection |
Reference escalation
| Weeks | Daily dose |
|---|---|
| 1–2 | 330–500 mcg |
| 3–4 | 500 mcg |
| 5–8 | 1 mg |
Reconstitution and syringe units
Our 10 mg vial is reconstituted with 1 ml of bacteriostatic water: it sits at 10 mg/ml.
The buttons follow the protocol's dose steps; the starting dose comes pre-selected.
Fill the syringe up to the 3.3 mark
The syringe: a 1 ml U-100 insulin syringe (numbered 0 to 100 U = 1 ml), sold at any pharmacy. Go by the printed numbers, not by counting lines.
It does not fit in a 1 ml syringe: split the draw in two or reconstitute with less water.
Open this calculation in the calculatorThe protocol week
See the full dose-to-units table
Units refer to an insulin U-100 syringe (100 units = 1 ml). Tap a figure to open it in the calculator. The last column shows how many complete doses the vial yields.
If you prefer coarser markings for the small starting doses, reconstitute with 3 ml instead of 1 —it sits at 3.3 mg/ml and 500 mcg goes from 5 to 15 units—. Check it in the calculator.
Documented precautions
- Caution with a history of anxiety, panic, bipolar disorder or psychotic disorders: Semax modulates dopaminergic and serotonergic signaling and can produce agitation, irritability, restlessness or insomnia.
- Discontinue if clinically significant psychiatric symptoms appear or worsen.
- Do not use in pregnancy or breastfeeding; the safety profile is not established in minors.
- Reported effects: headache, mild dizziness, rare and mild glucose elevation, injection-site reaction.
In our catalog
The 10 mg vial is on the SEMAX product page. In documented practice it accompanies NAD+ in energy and cognition lines, and is used as mood support during protocols with GLP agonists such as Tirzepatide.
Frequently asked questions
Why in the morning?
Semax is activating: it modulates dopamine and noradrenaline, and dosed late it can interfere with sleep. The reference places it first thing in the morning, with or without food — it is one of the few protocols in the catalog with no fasting condition or nighttime schedule.
How many units is 500 mcg?
With the house 1-to-1 rule (10 mg vial + 1 ml = 10 mg/ml), 500 mcg is 5 units in a U-100 syringe. With 3 ml of water the same dose is 15 units: easier to read if you prefer coarse markings.
How long does the 10 mg vial last?
In the 500 mcg stretch, 20 complete doses — about four weeks at 5 days per week. In the 1 mg stretch, 10 doses. A full 8-week cycle consumes between 28 and 42 mg depending on the starting dose and the days per week: 3 to 5 vials.
Injectable or nasal Semax?
Both routes are documented. Our catalog offers the lyophilized injectable format; the protocol on this page corresponds to that subcutaneous route.
Reference protocols compiled from documented research practice and adapted to our formats. Research-context documentation (RUO): not medical advice, not a prescription, and no substitute for professional evaluation.