Reference protocol: Semax
Semax is a nootropic and neuroprotective peptide dosed in the morning. Its escalation is short, and its main precaution is not physical but neuropsychiatric: it modulates dopamine, serotonin and BDNF, and that calls for respect with certain histories.
The reference for injectable Semax starts at 330 to 500 mcg per day in the morning —3.3 to 5 units at 10 mg/ml—, settles at 500 mcg in weeks 3 and 4, and rises to 1 mg —10 units— from week 5 to 8. Cycles of 6 to 8 weeks, with or without food.
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Your SEMAX vial arrives with the compound as a dry powder. Before using it you mix it with a special water — that step is called reconstitution — and measure each dose with an insulin syringe. Here is everything you need, in order.
- Get what you need: your vial, a vial of bacteriostatic water (not included — it is the special mixing water), a 1 ml U-100 insulin syringe — ask for it exactly like that at any pharmacy — and alcohol wipes.
- Mix the powder with the water (reconstitute): the vial is never uncapped — the needle goes through the rubber stopper. Add 1 ml of water letting it run down the inside wall, then swirl gently — never shake; it turns clear in a few minutes (some compounds take longer). Measure the water with the same insulin syringe: one full draw to the top is exactly 1 ml — do not repeat it. Once mixed, the vial goes in the fridge and lasts about 4 weeks; unmixed, also keep it refrigerated from the day it arrives.
- Fill the syringe up to the 3.3 mark: every small line on the insulin syringe is 1 unit (U). That mark equals the starting dose (330 mcg); if your dose is different, pick it in the panel below and the number updates. And note: several protocols raise the dose after the first weeks — the dose steps further down tell you when your mark changes.
- Inject under the skin and you are done: belly area (two fingers away from the navel), skin cleaned with alcohol; pinch the skin, insert the full needle and inject slowly. Switch sides each time and use a new syringe for every injection. Used in the morning, 5–7 days a week.
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Quick dictionary — the words that stop beginners
- Reconstitute: mixing the vial's powder with the special water so it becomes a liquid you can measure.
- Bacteriostatic water: the special water for that mix (regular water will not do); sold separately — one vial covers several mixes.
- Unit (U): each small line on the insulin syringe. 100 units = 1 ml.
- U-100 syringe: the standard 1 ml insulin syringe with 100 marks; sold at any pharmacy.
- mg and mcg: milligrams and micrograms: 1 mg = 1,000 mcg. Mind the factor of one thousand when reading a dose.
- Subcutaneous: an injection under the skin (not into muscle or vein), usually in the belly area.
- Cycle and washout: using the product for a period and then stopping completely for some weeks; when resuming you start again from the starting dose.
Quick facts
| Parameter | Reference |
|---|---|
| Frequency | 1 daily dose, 5–7 days per week |
| Time of day | In the morning |
| Fasting | Not required — with or without food |
| Cycle | 6–8 weeks · 6–8-week washout |
| Documented route | Subcutaneous injection |
Reference escalation
| Weeks | Daily dose |
|---|---|
| 1–2 | 330–500 mcg |
| 3–4 | 500 mcg |
| 5–8 | 1 mg |
Reconstitution and syringe units
Our 10 mg vial is reconstituted with 1 ml of bacteriostatic water: it sits at 10 mg/ml.
The buttons follow the protocol's dose steps; the starting dose comes pre-selected.
Fill the syringe up to the 3.3 mark
The syringe: a 1 ml U-100 insulin syringe (100 small marks = 1 ml), sold at any pharmacy.
Open this calculation in the calculatorThe protocol week
See the full dose-to-units table
Units refer to an insulin U-100 syringe (100 units = 1 ml). Tap a figure to open it in the calculator. The last column shows how many complete doses the vial yields.
If you prefer coarser markings for the small starting doses, reconstitute with 3 ml instead of 1 —it sits at 3.3 mg/ml and 500 mcg goes from 5 to 15 units—. Check it in the calculator.
Documented precautions
- Caution with a history of anxiety, panic, bipolar disorder or psychotic disorders: Semax modulates dopaminergic and serotonergic signaling and can produce agitation, irritability, restlessness or insomnia.
- Discontinue if clinically significant psychiatric symptoms appear or worsen.
- Do not use in pregnancy or breastfeeding; the safety profile is not established in minors.
- Reported effects: headache, mild dizziness, rare and mild glucose elevation, injection-site reaction.
In our catalog
The 10 mg vial is on the SEMAX product page. In documented practice it accompanies NAD+ in energy and cognition lines, and is used as mood support during protocols with GLP agonists such as Tirzepatide.
Frequently asked questions
Why in the morning?
Semax is activating: it modulates dopamine and noradrenaline, and dosed late it can interfere with sleep. The reference places it first thing in the morning, with or without food — it is one of the few protocols in the catalog with no fasting condition or nighttime schedule.
How many units is 500 mcg?
With the house 1-to-1 rule (10 mg vial + 1 ml = 10 mg/ml), 500 mcg is 5 units in a U-100 syringe. With 3 ml of water the same dose is 15 units: easier to read if you prefer coarse markings.
How long does the 10 mg vial last?
In the 500 mcg stretch, 20 complete doses — about four weeks at 5 days per week. In the 1 mg stretch, 10 doses. A full 8-week cycle consumes between 28 and 42 mg depending on the starting dose and the days per week: 3 to 5 vials.
Injectable or nasal Semax?
Both routes are documented. Our catalog offers the lyophilized injectable format; the protocol on this page corresponds to that subcutaneous route.
Reference protocols compiled from documented research practice and adapted to our formats. Research-context documentation (RUO): not medical advice, not a prescription, and no substitute for professional evaluation.